Ocular cicatricial disease. Drug effects in vitro on cell proliferation, contraction, and viability.

@article{Heath1990OcularCD,
  title={Ocular cicatricial disease. Drug effects in vitro on cell proliferation, contraction, and viability.},
  author={Timothy D. Heath and Carolyn S. Brown and Walter H. Stern},
  journal={Investigative ophthalmology & visual science},
  year={1990},
  volume={31 7},
  pages={1245-51}
}
Fluoroorotate, tunicamycin, and actinomycin D exhibit optimal effects on cell contractility if cells are exposed to the drug for 72 hr, followed by 24 hr of exposure during the contractility assay. Under these conditions, fluoroorotate and tunicamycin inhibit contractility at concentrations very similar to those required to inhibit proliferation, and at higher concentrations affect cell viability. In contrast, the concentrations at which actinomycin D inhibits cell contractility and viability… CONTINUE READING