Ocular changes in TgF344-AD rat model of Alzheimer's disease.

  title={Ocular changes in TgF344-AD rat model of Alzheimer's disease.},
  author={Yuchun Tsai and Bin Lu and Alexander V Ljubimov and Sergey Girman and Fred N. Ross-Cisneros and Alfredo Arrigo Sadun and Clive Niels Svendsen and Robert M. Cohen and Shaomei Wang},
  journal={Investigative ophthalmology & visual science},
  volume={55 1},
PURPOSE Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive decline in learning, memory, and executive functions. In addition to cognitive and behavioral deficits, vision disturbances have been reported in early stage of AD, well before the diagnosis is clearly established. To further investigate ocular abnormalities, a novel AD transgenic rat model was analyzed. METHODS Transgenic (Tg) rats (TgF344-AD) heterozygous for human mutant APPswe/PS1… CONTINUE READING