Ocular application of nerve growth factor protects degenerating retinal ganglion cells in a rat model of glaucoma.

@article{Colafrancesco2011OcularAO,
  title={Ocular application of nerve growth factor protects degenerating retinal ganglion cells in a rat model of glaucoma.},
  author={Valeria Colafrancesco and Vincenzo Parisi and Valentina Sposato and Simona Rossi and Matteo Antonio Russo and Marco Coassin and Alessandro Lambiase and Luigi Aloe},
  journal={Journal of glaucoma},
  year={2011},
  volume={20 2},
  pages={100-8}
}
PURPOSE Elevated intraocular pressure is a crucial pathologic event for the development of glaucoma (GL). We have reported that nerve growth factor (NGF) reaches retinal cells and the optic nerve (ON) when applied to the eye. Whether ocular application of NGF prevents or reduces damage to retinal ganglion cell (RGC) is not known. METHODS GL was induced in adult rats by the injection of hypertonic saline into the episcleral vein of the right eye and the left eye used as control. Rats were then… CONTINUE READING

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