Ocular activity of topically administered anandamide in the rabbit.

  title={Ocular activity of topically administered anandamide in the rabbit.},
  author={Yoichi Mikawa and Sumiko Matsuda and Takayasu Kanagawa and Tetsuya Tajika and Naoto Ueda and Yasunari Mimura},
  journal={Japanese journal of ophthalmology},
  volume={41 4},
Marijuana and its psychoactive constituents, cannabinoids, reduce intraocular pressure (IOP) in humans and animals. Because anandamide, a recently discovered endogenous ligand of cannabinoid receptors, reportedly shows cannabimimetic pharmacological activity, we examined its effect on the eye. Varying amounts of anandamide, in 50 microL of light mineral oil, were topically applied to a rabbit eye and changes in IOP and ocular symptoms were monitored. Anandamide (50 micrograms to 1 mg) induced a… CONTINUE READING