Ocular Surface Membrane-Associated Mucins.

  title={Ocular Surface Membrane-Associated Mucins.},
  author={Anna F. Ablamowicz and Jason J. Nichols},
  journal={The ocular surface},
  volume={14 3},
Ocular surface epithelial cells produce and secrete mucins that form a hydrophilic barrier for protection and lubrication of the eye. This barrier, the glycocalyx, is formed by high molecular weight heavily glycosylated membrane-associated mucins (MAMs) that include MUC1, MUC4, and MUC16. These mucins extend into the tear film from the anterior surfaces of the conjunctiva and cornea, and, through interactions with galectin-3, prevent penetrance of pathogens into the eye. Due primarily to the… CONTINUE READING

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