Ocular HSV-1 latency, reactivation and recurrent disease.

  title={Ocular HSV-1 latency, reactivation and recurrent disease.},
  author={Hassanain S Toma and Andrea Tesvich Murina and Raymond G Areaux and Donna M. Neumann and Partha Sarathi Bhattacharjee and Timothy P. Foster and Herbert E. Kaufman and James A. Hill},
  journal={Seminars in ophthalmology},
  volume={23 4},
Ocular infection with HSV-1 continues to be a serious clinical problem despite the availability of effective antivirals. Primary infection with HSV-1 can involve ocular and adenaxial sites and can manifest as blepharitis, conjunctivitis, or corneal epithelial keratitis. After initial ocular infection, HSV-1 can establish latent infection in the trigeminal ganglia for the lifetime of the host. During latency, the viral genome is retained in the neuron without producing viral proteins. However… CONTINUE READING
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