Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administered αvβ3 Integrin Antagonist, for the Treatment of Retinal Diseases.

@article{Askew2018OcularDA,
  title={Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administered αvβ3 Integrin Antagonist, for the Treatment of Retinal Diseases.},
  author={Ben C Askew and Takeru Furuya and Drake S Edwards},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2018},
  volume={366 2},
  pages={
          244-250
        }
}
SF0166, a small-molecule αvβ3 antagonist, has physiochemical properties that allow distribution to the posterior segment of the eye after topical administration in an ophthalmic solution. The pharmacodynamics and ocular distribution of SF0166 were evaluated in several cell lines, chick chorioallantoic membrane assays, and models of ocular neovascularization… CONTINUE READING