Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways.

@article{Lee2008OctylphenolSR,
  title={Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways.},
  author={M. H. Lee and Heng Lin and Chi-Wei Liu and Min-Hua Wu and Wei-Ju Liao and Hsin-Huei Chang and Hui-Chen Ku and Yeh-Sheng Chien and W H Ding and Yung-hsi Kao},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={294 6},
  pages={C1542-51}
}
Resistin is known as an adipocyte-specific secretory hormone that can cause insulin resistance and decrease adipocyte differentiation. It can be regulated by sexual hormones. Whether environmental estrogens regulate the production of resistin is still not clear. Using 3T3-L1 adipocytes, we found that octylphenol upregulated resistin mRNA expression in dose- and time-dependent manners. The concentration of octylphenol that increased resistin mRNA levels by 50% was approximately 100 nM within 6 h… CONTINUE READING
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