Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial.

@article{Cascinu1993OctreotideVL,
  title={Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial.},
  author={Stefano Cascinu and A. Fedeli and Stefano Luzi Fedeli and G. Catalano},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1993},
  volume={11 1},
  pages={148-51}
}
PURPOSE Diarrhea is a prominent feature of fluorouracil (5FU) gastrointestinal toxicity, especially when 5FU is combined with leucovorin (LV) or interferon (IFN). No treatment for this condition has been well defined, although drugs, such as diphenoxylate or loperamide, generally are used. The efficacy of octreotide in the treatment of 5FU-induced diarrhea recently has been reported. We performed a randomized trial that compared octreotide with loperamide, the drug most commonly used for… CONTINUE READING
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