Octopamine inhibits synaptic transmission at the larval neuromuscular junction in Drosophila melanogaster.

@article{Nishikawa1999OctopamineIS,
  title={Octopamine inhibits synaptic transmission at the larval neuromuscular junction in Drosophila melanogaster.},
  author={Kohki Nishikawa and Yoshiaki Kidokoro},
  journal={Brain research},
  year={1999},
  volume={837 1-2},
  pages={67-74}
}
The effect of octopamine, a biogenic amine, on synaptic transmission at the neuromuscular junction (NMJ) in first instar larvae of Drosophila melanogaster was examined using the patch clamp technique. Muscle cells were voltage-clamped at -60 mV in the whole-cell configuration, and nerve-evoked excitatory junctional currents (EJCs) and miniature excitatory junctional currents (MEJCs) were recorded. Octopamine significantly decreased the mean amplitude of nerve-evoked EJCs in a dose-dependent… CONTINUE READING
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