Octapeptide repeat insertions in the prion protein gene and early onset dementia.

  title={Octapeptide repeat insertions in the prion protein gene and early onset dementia.},
  author={Esther A. Croes and Jessie Theuns and Jeanine J. Houwing-Duistermaat and Bart Dermaut and Kristel Sleegers and Gerwin Roks and Marleen van den Broeck and Barbera Van Harten and John Cornelis van Swieten and Marc Cruts and Christine van Broeckhoven and Cornelia M van Duijn},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={75 8},
OBJECTIVES The most common familial early onset dementia mutations are found in the genes involved in Alzheimer's disease; the amyloid precursor protein (APP) and the presenilin 1 and 2 (PSEN1 and 2) genes; the prion protein gene (PRNP) may be involved. METHODS Following identification of a two-octapeptide repeat insertion in PRNP, we conducted a meta-analysis to investigate the relation of number of PRNP octapeptide repeats with age at disease onset and duration of illness; identifying 55… CONTINUE READING
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