Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.

  title={Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.},
  author={Bin He and Stacey Rhodes-Brower and Michael R Miller and Albert E. Munson and Dori R. Germolec and Vickie R Walker and Kenneth S. Korach and Barbara Jean Meade},
  journal={Toxicology and applied pharmacology},
  volume={192 3},
Octamethylcyclotetrasiloxane (D4) is a low molecular weight cyclic silicone used in the synthesis of larger silicone polymers and in the formulation of a variety of personal care products. The effects of oral D4 exposure in mice on serum estradiol levels, uterine wet weight, and uterine peroxidase activity were investigated. Additionally, in vitro estrogen receptor binding activity was evaluated. Serum estradiol levels decreased in a dose-dependent manner after exposure to 100 mg/kg to 1000 mg… CONTINUE READING
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