Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases.

@article{Phelan2000OctamerTA,
  title={Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases.},
  author={M L Phelan and Gavin R. Schnitzler and Robert E. Kingston},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 17},
  pages={6380-9}
}
Chromatin remodeling complexes help regulate the structure of chromatin to facilitate transcription. The multisubunit human (h) SWI-SNF complex has been shown to remodel mono- and polynucleosome templates in an ATP-dependent manner. The isolated hSWI-SNF ATPase subunits BRG1 and hBRM also have these activities. The intact complex has been shown to produce a stable remodeled dimer of mononucleosomes as a product. Here we show that the hSWI-SNF ATPases alone can also produce this product. In… CONTINUE READING

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