Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery

@article{Khalil2007OctaargininemodifiedME,
  title={Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery},
  author={Ikramy A Khalil and Kentaro Kogure and Shiro Futaki and Susumu Hama and Hidetaka Akita and Masaru Ueno and Hitaru Kishida and Masafumi Kudoh and Yuji Mishina and Kazunori Kataoka and Masato Yamada and Hideyoshi Harashima},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={682-689}
}
This study describes a multifunctional envelope-type nano device (MEND) that mimics an envelope-type virus based on a novel packaging strategy. MEND particles contain a DNA core packaged into a lipid envelope modified with an octaarginine peptide. The peptide mediates internalization via macropinocytosis, which avoids lysosomal degradation. MEND-mediated transfection of a luciferase expression plasmid achieved comparable efficiency to adenovirus-mediated transfection, with lower associated… CONTINUE READING

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