Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm.

@article{Aksoy2013Oct4SP,
  title={Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm.},
  author={Ir{\`e}ne Aksoy and Ralf Jauch and Jia-Xuan Chen and Mateusz Dyla and Ushashree Divakar and Gireesh K. Bogu and Roy Tang Yi Teo and Calista Keow Leng Ng and Wishva Herath and Sun Li-li and Andrew P. Hutchins and Paul Robson and Prasanna R. Kolatkar and Lawrence W. Stanton},
  journal={The EMBO journal},
  year={2013},
  volume={32 7},
  pages={
          938-53
        }
}
How regulatory information is encoded in the genome is poorly understood and poses a challenge when studying biological processes. We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification. We show that Sox17 partners with Oct4 and binds to a unique 'compressed' Sox/Oct motif that earmarks endodermal genes. This is in contrast to the pluripotent state where Oct4 selectively partners with… CONTINUE READING

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