Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells.

  title={Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells.},
  author={Charn-Jung Chang and Yueh Hsiu Chien and Kai-Hsi Lu and Shih-Ching Chang and Yueh-Ching Chou and C Huang and Chin-hong Chang and Kuan-Hsuan Chen and Yuh-Lih Chang and L. S. Tseng and Wen-Shin Song and Jhi-Joung Wang and J Lin and Pin-I Huang and Yuan-Tzu Lan},
  journal={Biochemical and biophysical research communications},
  volume={415 2},
Oct4, a member of the POU-domain transcription factor family, has been implicated in the cancer stem cell (CSC)-like properties of various cancers. However, the precise role of Oct4 in colorectal CSC initiation remains uncertain. Numerous studies have demonstrated a strong link between inflammation and tumorigenesis in colorectal cancers. In this study, we demonstrated that Oct4 overexpression enhances CSC-like properties of colorectal cancer cells (CRCs), including sphere formation, cell… CONTINUE READING


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