Oct4 pseudogenes are transcribed in cancers.

  title={Oct4 pseudogenes are transcribed in cancers.},
  author={Guangli Suo and Jin Han and Xia Wang and Jingyu Zhang and Yannan Zhao and Yanhong Zhao and Jianwu Dai},
  journal={Biochemical and biophysical research communications},
  volume={337 4},
Octamer-binding transcription factor 4 (Oct4) plays a critical role for maintaining pluripotent and the self-renewing state of stem cells. Recent studies demonstrated that Oct4 gene was expressed in human cancers. Six pseudogenes of Oct4 have been proposed by using bioinformatics approach to analyze the genomic nucleotide sequences. Here, we reported that an Oct4 pseudogene localized in human chromosome 10 (Oct4-pg5) and a pseudogene in chromosome 8 (Oct4-pg1) were transcribed in cancer cell… CONTINUE READING