Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.

@article{Levasseur2008Oct4DO,
  title={Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.},
  author={Dana N. Levasseur and Jianlong Wang and Michael Dorschner and John A. Stamatoyannopoulos and Stuart H Orkin},
  journal={Genes & development},
  year={2008},
  volume={22 5},
  pages={575-80}
}
Embryonic stem (ES) cells offer insight into early developmental fate decisions, and their controlled differentiation may yield vast regenerative potential. The molecular determinants supporting ES cell self-renewal are incompletely understood. The homeodomain proteins Nanog and Oct4 are essential for mouse ES cell self-renewal. Using a high-throughput approach, we discovered DNaseI hypersensitive sites and potential regulatory elements along a 160-kb region of the genome that includes GDF3… CONTINUE READING
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