Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst.

@article{Frum2013Oct4CP,
  title={Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst.},
  author={Tristan Frum and Michael A. Halbisen and Chaoyang Wang and Hossein Amiri and Paul Robson and Amy Ralston},
  journal={Developmental cell},
  year={2013},
  volume={25 6},
  pages={610-22}
}
In embryonic stem (ES) cells and in early mouse embryos, the transcription factor Oct4 is an essential regulator of pluripotency. Oct4 transcriptional targets have been described in ES cell lines; however, the molecular mechanisms by which Oct4 regulates establishment of pluripotency in the epiblast (EPI) have not been fully elucidated. Here, we show that neither maternal nor zygotic Oct4 is required for the formation of EPI cells in the blastocyst. Rather, Oct4 is first required for… CONTINUE READING
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