Oct4 and its pseudogenes confuse stem cell research.

@article{Liedtke2007Oct4AI,
  title={Oct4 and its pseudogenes confuse stem cell research.},
  author={Stefanie Liedtke and Juergen Enczmann and Simon Waclawczyk and Peter Wernet and Gesine Koegler},
  journal={Cell stem cell},
  year={2007},
  volume={1 4},
  pages={
          364-6
        }
}
Octamer-binding transcription factor 4 ( Oct4 ) encodes a nuclear protein that belongs to a family of transcription factors containing the POU DNA binding domain. It is specifically expressed in embryonic stem cells but can also be detected in adult stem cells such as bone marrow-derived mesenchymal stem cells. The expression of Oct4 is down-regulated coincident with stem cell differentiation and loss of expression leading to differentiation. It plays a critical role for maintaining… CONTINUE READING

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