Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis.

@article{Wen2010Oct4AN,
  title={Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis.},
  author={Jing Wen and Jeong Youp Park and Kyung Hwa Park and Hye Won Chung and Seungmin Bang and Seung Woo Park and Si Young Song},
  journal={Pancreas},
  year={2010},
  volume={39 5},
  pages={622-6}
}
OBJECTIVE To characterize the role of Oct4 and Nanog, two important homeobox transcription factors of embryonic development, in pancreatic carcinogenesis. METHODS Using a tissue microarray of human pancreatic carcinoma and adjacent noncancerous tissues as well as the N-nitrosobis(2-oxopropyl)amine-induced Syrian golden hamster pancreatic cancer model, we characterized the expression of Oct4 and Nanog. The presence of K-ras mutation with the time course of carcinogenesis in hamster model was… CONTINUE READING