Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Müller Glia Dedifferentiation in a Murine Model of Retinal Injury

@inproceedings{ReyesAguirre2016Oct4MS,
  title={Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing M{\"u}ller Glia Dedifferentiation in a Murine Model of Retinal Injury},
  author={Luis I. Reyes-Aguirre and M{\'o}nica Lamas},
  booktitle={Front. Neurosci.},
  year={2016}
}
Müller glia (MG) is the most abundant glial type in the vertebrate retina. Among its many functions, it is capable of responding to injury by dedifferentiating, proliferating, and differentiating into every cell types lost to damage. This regenerative ability is notoriously absent in mammals. We have previously reported that cultured mammalian MG undergoes… CONTINUE READING