Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity.

  title={Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity.},
  author={Rita Aires and Arnon Dias Jurberg and Francisca Leal and Ana N{\'o}voa and Martin J Cohn and Moises Mallo},
  journal={Developmental cell},
  volume={38 3},
Vertebrates exhibit a remarkably broad variation in trunk and tail lengths. However, the evolutionary and developmental origins of this diversity remain largely unknown. Posterior Hox genes were proposed to be major players in trunk length diversification in vertebrates, but functional studies have so far failed to support this view. Here we identify the pluripotency factor Oct4 as a key regulator of trunk length in vertebrate embryos. Maintaining high Oct4 levels in axial progenitors… CONTINUE READING


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