Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation.

@article{Cao2008Oct25RT,
  title={Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation.},
  author={Ying Cao and Doreen Siegel and Franz Oswald and Walter Knoechel},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 49},
  pages={34168-77}
}
The balance between differentiation signals and signals maintaining the undifferentiated state of embryonic cells ensures proper formation of germ layers. The nodal/activin pathway represents one of the major signaling chains responsible for the differentiation of embryonic cells into mesodermal and endodermal germ layers, while Oct4 is one of the major players in the maintenance of an undifferentiated state. Here we show that Oct25, an Oct4 homologue in Xenopus, antagonizes the activity of… CONTINUE READING