Oct-4 mRNA and protein expression during human preimplantation development.

  title={Oct-4 mRNA and protein expression during human preimplantation development.},
  author={Greet Cauffman and Hilde van de Velde and Inge Liebaers and Andr{\'e} C. van Steirteghem},
  journal={Molecular human reproduction},
  volume={11 3},
The transcription factor OCT-4 is regarded as a critical factor in controlling mammalian early embryonic development because of its role in toti-/pluripotency. In human preimplantation embryos, OCT-4 studies are limited to RNA analysis of abnormally developing embryos. This study thoroughly investigated the expression pattern of OCT-4 throughout the human preimplantation development. Expression was examined by single-cell RT-PCR or indirect immunocytochemistry in 36 single oocytes of various… CONTINUE READING
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