Oct-4 Expression Maintained Cancer Stem-Like Properties in Lung Cancer-Derived CD133-Positive Cells

@article{Chen2008Oct4EM,
  title={Oct-4 Expression Maintained Cancer Stem-Like Properties in Lung Cancer-Derived CD133-Positive Cells},
  author={Yu-Chih Chen and H Hsu and Yi-Wei Chen and Tung-Hu Tsai and Chorng-Kuang How and C T Wang and S. -Y. Hung and Yuh-Lih Chang and Ming-Long Tsai and Y F Lee and H. L. Ku and Shih-Hwa Chiou},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={379 - 392}
}
CD133 (prominin-1), a 5-transmembrane glycoprotein, has recently been considered to be an important marker that represents the subset population of cancer stem-like cells. Herein we report the isolation of CD133-positive cells (LC-CD133(+)) and CD133-negative cells (LC-CD133(-)) from tissue samples of ten patients with non-small cell lung cancer (LC) and five LC cell lines. LC-CD133(+) displayed higher Oct-4 expressions with the ability to self-renew and may represent a reservoir with… CONTINUE READING
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