Oct-2-en-4-ynoyl-CoA as a specific inhibitor of acyl-CoA oxidase.

  title={Oct-2-en-4-ynoyl-CoA as a specific inhibitor of acyl-CoA oxidase.},
  author={Jia Zeng and Long Jun Wu and Xiaojian Zhang and Yuandong Liu and Guisheng Deng and Ding Yang Li},
  journal={Organic letters},
  volume={10 19},
Oct-2-en-4-ynoyl-CoA was found to be a specific inhibitor of acyl-CoA oxidase in fatty acid oxidation in peroxisomes that has no inhibitory effect on acyl-CoA dehydrogenase in mitochondria. The inhibition reaction involves a nucleophilic attack of Glu421 to the delta carbon of the inhibitor. The result indicates that acyl-CoA oxidase and acyl-CoA… CONTINUE READING