Oct‐3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β‐catenin signalling

@article{AbuRemaileh2010Oct34RS,
  title={Oct‐3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/$\beta$‐catenin signalling},
  author={Monther Abu-Remaileh and Ariela Gerson and Marganit Farago and Gili Nathan and Irit Alkalay and Sharon Zins Rousso and Michal Gur and Abraham Fainsod and Yehudit Bergman},
  journal={The EMBO Journal},
  year={2010},
  volume={29}
}
Although the transcriptional regulatory events triggered by Oct‐3/4 are well documented, understanding the proteomic networks that mediate the diverse functions of this POU domain homeobox protein remains a major challenge. Here, we present genetic and biochemical studies that suggest an unexpected novel strategy for Oct‐3/4‐dependent regulation of embryogenesis and cell lineage determination. Our data suggest that Oct‐3/4 specifically interacts with nuclear β‐catenin and facilitates its… Expand
Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells.
TLDR
The expression and function of Wnt/ß-catenin signalling elements during the early stages of mouse development are summarized and the reasons why the requirement in ES cells do not reflect the embryo are considered. Expand
Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
TLDR
It is demonstrated that OCT4 represses β- catenin signaling during self-renewal and that targeted knockdown of OCT4 activates β-catenin signaled in hESCs, which support a dominant role for Wnt/β-catanin signaling in the differentiation rather than self-Renewal of hESC. Expand
A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells
TLDR
The results suggest that the function of the network is to buffer the transcriptional activity of Oct4, which appears to be the main determinant to exit pluripotency. Expand
A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells
TLDR
It is shown that during self-renewal there is negligible transcriptional activity of β-catenin and that this is due to its tight association with membranes, where it finds it in a complex with Oct4 and E-cadherin. Expand
WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts.
TLDR
It is concluded that WNT3 and membrane-associated β-catenin promote progenitor trophoblast development in human blastocysts and have important implications in assisted reproduction and stem cell biology. Expand
Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo
TLDR
Recent progress towards understanding the regulation of canonical WNT/β‐ catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the availability of intracellular pools of active β‐catenin and the cross‐regulation of the WNT activity by β‐Catenin independent pathway is summarized. Expand
Wnt3a-dependent and -independent Protein Interaction Networks of Chromatin-bound β-catenin in Mouse Embryonic Stem Cells
TLDR
Proof-of-principle experiments show that β-catenin can recruit the H3K4me2/1 demethylase LSD1 to regulate the expression of the tumor suppressor Lefty1 in mouse embryonic stem cells. Expand
The development of an organism results from the regulated convergence of two processes: the activity of genetic programmes that fuel the generation of different kinds of cells over time, and the organization of these into three dimensional structures
Wnt/ß-catenin signalling is a widespread cell signalling pathway with multiple roles during vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for ßcatenin: it promotesExpand
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies
TLDR
This review is intended to serve as a refresher of the current understanding about the physiologic and pathogenic roles of WNT/β-catenin signaling pathway, and to outline potential therapeutic opportunities by targeting the canonical WNT pathway. Expand
β-Catenin in pluripotency: adhering to self-renewal or Wnting to differentiate?
TLDR
New data concerning adhesion- and transcription-related activities of β-catenin in control of self-renewal versus differentiation in pluripotent stem cells are focused on, as well as analyzing binding partners ofβ-catanin in embryonic stem cells, which include key pluripotency regulators. Expand
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