Ochratoxin A induces apoptosis in neuronal cells

  title={Ochratoxin A induces apoptosis in neuronal cells},
  author={Xiangnan Zhang and Christine Boesch-Saadatmandi and Yijia Lou and Siegfried J Wolffram and Patricia Huebbe and Gerald H Rimbach},
  journal={Genes & Nutrition},
The mycotoxin ochratoxin A (OTA), which is produced by Aspergillus and Penicillium subspecies, is a frequently present contaminant of food and feedstuffs. OTA exhibits a wide range of toxic activities including nephro- and hepatotoxicity. However, little is known regarding potential neurotoxic effects of OTA. In the present study primary neurons as well as SH-SY5Y neuronal cells were incubated with increasing concentrations of OTA (0.1–2.5 μmol/L). OTA treatment resulted in a dose-dependent… CONTINUE READING