Ochratoxin A induced premature senescence in human renal proximal tubular cells.

@article{Yang2017OchratoxinAI,
  title={Ochratoxin A induced premature senescence in human renal proximal tubular cells.},
  author={Xuan Yang and Sheng Liu and Chuchu Huang and Haomiao Wang and Yunbo Luo and Wentao Xu and Kunlun Huang},
  journal={Toxicology},
  year={2017},
  volume={382},
  pages={75-83}
}
Ochratoxin A (OTA) has many nephrotoxic effects and is a promising compound for the study of nephrotoxicity. Human renal proximal tubular cells (HKC) are an important model for the study of renal reabsorption, renal physiology and pathology. Since the induction of OTA in renal senescence is largely unknown, whether OTA can induce renal senescence, especially at a sublethal dose, and the mechanism of OTA toxicity remain unclear. In our study, a sublethal dose of OTA led to an enhanced senescent… CONTINUE READING