Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome.

@article{Moon2006OchnaflavoneNO,
  title={Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome.},
  author={Tae Chul Moon and Hwa Shin Hwang and Zhejiu Quan and Kun Ho Son and Cheorl-Ho Kim and Hyun Pyo Kim and Shin Sung Kang and Jeong Kwon Son and Hyeun Wook Chang},
  journal={Biological & pharmaceutical bulletin},
  year={2006},
  volume={29 12},
  pages={
          2359-61
        }
}
This study investigated the protective effects of a group IIA secretory phospholipase A2 (sPLA2-IIA) inhibitor, ochnaflavone, on the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rat liver microsomes in vitro. When rat liver was incubated at 37 degrees C in the presence of CCl4, the level of phosphatidylethanolamine (PE) degradation increased markedly compared with the control. The rat 14 kDa platelet PLA2 antibody, R377, suppressed the degradation of PE. Pretreating… CONTINUE READING