Occurrence of the aminoacyl-tRNA synthetases in high-molecular weight complexes correlates with the size of substrate amino acids.


One of the distinctive and mysterious features of mammalian aminoacyl-tRNA synthetases (AARSs) is the existence of stable high-molecular weight complexes containing 10 out of 20 AARSs. The composition and structure of these complexes are conserved among multicellular animals. No specific function associated with these structures has been found, and there is… (More)


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