Occurrence of subcortical hyperintensities in elderly subjects with mania.

  title={Occurrence of subcortical hyperintensities in elderly subjects with mania.},
  author={William W. McDonald and K. Ranga R. Krishnan and P. Murali Doraiswamy and Dan German Blazer},
  journal={Psychiatry research},
  volume={40 4},
In a retrospective study, brain magnetic resonance images of 12 patients with the onset of manic symptoms after the age of 50 years were compared to age- and sex-matched control subjects for the incidence, size, and location of subcortical hyperintensities. Compared with controls, the patients demonstrated a significantly greater number of large subcortical hyperintensities, particularly in the middle third of the brain parenchyma. The lesions occurred with equal frequency in the right and left… CONTINUE READING

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