Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

  title={Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques},
  author={Heiko Braak and E. van Braak and Inge Grundke‐Iqbal and Khalid Iqbal},
  journal={Neuroscience Letters},
Paired helical filaments, pathologically changed components of the cytoskeleton of human nerve cells, are demonstrated by a specific silver staining technique, immunostaining and electron microscopy. Accumulations of these filaments are found in the telencephalic cortex of old-aged individuals and patients suffering from Alzheimer's disease. Apart from neurofibrillary tangles and neuritic plaques, paired helical filaments are encountered in neuropil threads. At this third location, pathological… Expand
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques
Thread-like structures immunoreactive with paired helical filaments and tau antisera demonstrated as mesh-works in the neocortices of five brains with Alzheimer-type dementia, but not in those of five normal aged control brains suggest that wide-spread change of the Neuropil neurites, neuropil threads or curly fibers are dendritic in origin and play an important role in the clinical manifestation of dementia. Expand
Neurofibrillary tangles in the cerebral cortex of sheep
The presence of structures in the cerebral cortex of sheep, Ovis aries, that resemble Alzheimer NFTs and neuritic plaques are reported. Expand
Tau-reactive neurofibrillary tangles in cerebellar cortex from patients with Alzheimer's disease
In 4 cases of Alzheimer's disease a tau antiserum immunostained thin, round or flame-shaped profiles disposed around the nuclei of the cerebellar fusiform-type Golgi cells, indicating that in AD the NFT formation is more diffuse than that showed with conventional histological methods. Expand
Beta-amyloid deposition and paired helical filament formation: Which histopathological feature is more significant in Alzheimer's disease?
Paired helical filament formation in perikarya (neurofibrillary tangles) and the neuropil of the cerebrum appears to be the histopathological feature that is most characteristic of AD. Expand
Morphology of neurofibrillary tangles and senile plaques
Abnormal filaments (PHF) accumulate in neurons in Alzheimer’s disease in target areas. They fill the pericaryon but are also found in dendrites and axons. Their presence is associated with aExpand
Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton
  • G. Perry, M. Kawai, +6 authors P. Gambetti
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1991
It is concluded that straight filaments are likely to replace neurofilaments, that they in turn might be replaced by paired helical filaments, and that this process occurs in axons as well as dendrites. Expand
Paired helical filament morphology varies with intracellular location in Alzheimer's disease brain
The results reveal the presence of two distinct PHF populations and investigation of their relationship may shed light on the pathogenesis of AD. Expand
Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes
Brains from 56 individuals suffering from adult onset dementia and devoid of macroscopically detectable infarctions showed the characteristic cytoskeleton changes of Alzheimer's disease, but eight brains showed the presence of abnormal and intensely argyrophilic grains loosely scattered throughout the neuropil. Expand
The presubicular region in Alzheimer's disease: topography of amyloid deposits and neurofibrillary changes
Severe involvement of all subdivisions of the presubicular region in Alzheimer's disease is considered to impair functions of the Papez circuit. Expand
Localisation and association of pathomorphological changes at the brainstem in Alzheimer's disease
It is concluded that neuronal connectivity plays an important role in the pathogenesis of Alzheimer's disease lesions and may be due to the intraneuronal transport of beta-amyloid precursor protein. Expand


Neurofibrillary tangles of paired helical filaments
These studies showed that the "twisted tubule" which makes up the neurofibrillary tangle in many pathological situations is a bifilar helix made up of 130 A filaments. Expand
Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease
  • M. Kidd
  • Chemistry, Medicine
  • Nature
  • 1963
Well-known findings would lead one to expect the presence of fine filaments associated with these cells in the electron microscope, and if intra-cellular, these might be neurofilaments, which are suggested by Gray and Guillery2 to be the basis of neurofibrillary argyro-philia. Expand
Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.
It is concluded that these epitopes are integral components of the paired helical filaments and that, at least in part, paired helicals filaments are derived from altered elements of the normal neuronal cytoskeleton. Expand
Silver staining of Alzheimer's neurofibrillary changes by means of physical development.
  • F. Gallyas
  • Biology, Medicine
  • Acta morphologica Academiae Scientiarum Hungaricae
  • 1971
  • R. Terry
  • Medicine
  • Journal of neuropathology and experimental neurology
  • 1963