The present study reported the first observation of isopod parasite, Nerocila phaiopleura infestation on Chirocentrus nudus an economically important fish from Cuddalore coast, Southeast coast of India. The maximum prevalence of 6.3 % and mean intensity of 3.2 were observed during pre-monsoon 2010 and monsoon 2010 respectively. The highest intensity 7 was observed in the single host during monsoon. The site of attachment leads to wound and offer the secondary infection. Two pathogenic bacteria Streptococcus aureus and E. coli were isolated from the wound.