Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation.

@article{Harding1992OccurrenceOA,
  title={Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation.},
  author={Anita E. Harding and Mary G. Sweeney and David H. Miller and Colin John Mumford and H. F. Kellar-Wood and Didier M{\'e}nard and W. Ian McDonald and D. Alastair S. Compston},
  journal={Brain : a journal of neurology},
  year={1992},
  volume={115 ( Pt 4)},
  pages={979-89}
}
Eight women are described who presented with bilateral, usually sequential, optic neuropathy, six of whom later developed a neurological syndrome indistinguishable from multiple sclerosis (MS). Magnetic resonance imaging, performed in five of the patients with an MS-like illness and in the two others with optic neuropathy alone, showed widespread white matter lesions as seen in MS. All of these women had matrilineal relatives with Leber's hereditary optic neuropathy, although this was not… CONTINUE READING

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