Occurrence of O‐linked Xyl‐GlcNAc and Xyl‐Glc disaccharides in trocarin, a factor Xa homolog from snake venom

@article{Joseph2003OccurrenceOO,
  title={Occurrence of O‐linked Xyl‐GlcNAc and Xyl‐Glc disaccharides in trocarin, a factor Xa homolog from snake venom},
  author={J. Joseph and M. Valiyaveettil and D. Gowda and R. Kini},
  journal={Journal of Thrombosis and Haemostasis},
  year={2003},
  volume={1}
}
Summary.  Trocarin is a 46515‐Da group D prothrombin‐activating glycoprotein from the venom of the Australian elapid, Tropidechis carinatus. Amino acid sequencing and functional characterization of trocarin demonstrated that it is a structural and functional homolog of mammalian blood coagulation factor (F)Xa. In this study we show that, in contrast to mammalian Xa, which is not glycosylated, trocarin contains an O‐linked carbohydrate moiety in its light chain and an N‐linked carbohydrate… Expand
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