Occurrence of D-aspartic acid in rat brain pineal gland.

  title={Occurrence of D-aspartic acid in rat brain pineal gland.},
  author={Kazuhiro Imai and Takeshi Fukushima and Kayoko Hagiwara and Tomofumi Santa},
  journal={Biomedical chromatography : BMC},
  volume={9 2},
We found a high concentration (1030 pmol per pineal gland) of D-aspartic acid (D-Asp) in the pineal gland of 6-week-old Sprague-Dawley (SD) rats. The content of D-Asp decreased with age, being 210 and 33 pmol per pineal gland in 28- and 45-week-old rats respectively. The proportion of D-Asp [(D-Asp/total Asp) x 100] also decreased with age, declining from 66% to 10% between 6 and 45 weeks after birth. The proportion of D-Asp did not differ between the sexes. The concentration of D-Asp was… CONTINUE READING