Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease.

@article{Meyers1981OccurrenceOC,
  title={Occurrence of Clostridium difficile toxin during the course of inflammatory bowel disease.},
  author={Susan Meyers and Lloyd Hitoshi Mayer and Edward Bottone and Edward Desmond and Henry D. Janowitz},
  journal={Gastroenterology},
  year={1981},
  volume={80 4},
  pages={697-70}
}
Clostridium difficile toxin, the presumed mechanism of antibiotic-associated pseudomembranous colitis, has been suggested as a contributory factor to mucosal injury in inflammatory bowel disease. We evaluated its incidence and apparent role in 65 consecutive patients with diarrheal and inflammatory bowel diseases. Toxin was demonstrated in 3 of 18 patients with ulcerative colitis (17%), 1 of 26 with Crohn's colitis (4%), and 5 of 21 with a variety of diarrheal illnesses (24%). Toxin appeared… CONTINUE READING
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