Occurrence of Bufotenin in the Urine of Schizophrenic Patients and Normal Persons

@article{Faurbye1968OccurrenceOB,
  title={Occurrence of Bufotenin in the Urine of Schizophrenic Patients and Normal Persons},
  author={Arild Faurbye and K Pind},
  journal={Nature},
  year={1968},
  volume={220},
  pages={489-489}
}
BECAUSE of conflicting statements about the occurrence of bufotenin in the urine of schizophrenics and normal subjects1–13 we have now developed a method which allows semi-quantitative estimation of about 0.7 µg total bufotenin in 24 h urine samples. The method consists of purification and isolation by successive column chromatography, sublimation, paper chromatography and thin-layer chromatography. 

Potentiation in Rats of Bufotenin-Induced Behavioral Changes by Chlorpromazine

The data illustrate that pretreatment of the rat with chlorpromazine potentiates the behavioral effects of bufotenin, while pretreatment with a tricyclic antidepressant drug does not alter the dose-response relationship for bufOTenin.

A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010.

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The continuous-addition-of-reagent (CAR) technique was used for the determination of hallucinogenic alkaloids such as N-methyltryptamine, 5-methyltryptamine, α-methyltryptamine, bufotenine and

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A great deal of information is accumulating about the biochemical abnormalities which might be characteristic of so-called schizophrenics.

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References

SHOWING 1-10 OF 11 REFERENCES

Psychotomimetic Indole Compound in the Urine of Schizophrenics and Mentally Defective Patients

A bufotenin-like compound has been reported in the urine of schizophrenic patients and these findings have not been generally accepted because of some defects in the detection methods employed.

FAILURE TO DETECT 3,4‐DIMETHOXYPHENYLETHYLAMINE IN THE URINE OF PSYCHOTIC CHILDREN

  • A. FaurbyeK. Pind
  • Psychology, Medicine
    Acta psychiatrica Scandinavica. Supplementum
  • 1966
In 1962 Friedhoff & Van Winkle reported that in the urine of 15 out of 19 acute schizophrenic patients they had found a compound which they identified as 3,4-dimethoxyphenylethylamine (DMPEA), and since then several authors have investigated the occurrence of DMPEA in schizophrenia in adults.

Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds

An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also

URINARY EXCRETION OF AMINES IN NORMAL CHILDREN

It is suggested that study of the excretion of amines in the urine of children who are mentally defective or mentally ill, and comparison with the pattern of urinary amine excretion in normal children, may provide clues to the mechanisms of certain forms of cerebral dysfunction.

The role of amines in the etiology of schizophrenia.