Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition.

@article{Herz2012OccurrenceOA,
  title={Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition.},
  author={Corinna Herz and Fabienne Schluermann and Daniela Batarello and Christiane Daniela Fichter and Anja Schoepflin and Claudia M{\"u}nch and Dieter Hauschke and Martin Werner and Silke Lassmann},
  journal={Molecular carcinogenesis},
  year={2012},
  volume={51 9},
  pages={696-710}
}
Aurora A "over-"expression may induce supernumerary centrosomes, respective multipolar mitoses, and aneuploidy. Here, we examined Aurora A positive multipolar mitoses in aneuploid, microsatellite-stable (MSS, "CIN-type") versus near-diploid, microsatellite-instable (MSI, "MIN-type") colorectal carcinomas (CRC) and CRC cell lines as well as the effect of Aurora A inhibition in CRC cell lines. In situ, three-dimensional immunofluorescence (3D-IF) revealed Aurora A positive multipolar mitoses in… CONTINUE READING
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