Occurrence of β‐methylamino‐l‐alanine (BMAA) in ALS/PDC patients from Guam

  title={Occurrence of $\beta$‐methylamino‐l‐alanine (BMAA) in ALS/PDC patients from Guam},
  author={S. Murch and P. Cox and S. Banack and J. Steele and O. Sacks},
  journal={Acta Neurologica Scandinavica},
We tested the brain tissues of the Chamorro people of Guam who died of amyotrophic lateral sclerosis/Parkinsonism dimentia complex (ALS/PDC) for the neurotoxin β‐methylamino‐l‐alanine (BMAA). We used validated high‐pressure liquid chromatography and liquid chromatography‐mass spectrometry analyses to test well‐characterized archival tissues of the superior frontal gyrus from eight Chamorros from Guam and a comparison group of 15 Canadians. BMAA was found as a free amino acid in 83% of Chamorro… Expand
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