Occurrence of Γ-globulin Complexes in Serum and Joint Fluid of Rheumatoid Arthritis Patients: Use of Monoclonal Rheumatoid Factors as Reagents for Their Demonstration

@article{Winchester1971OccurrenceO,
  title={Occurrence of Γ-globulin Complexes in Serum and Joint Fluid of Rheumatoid Arthritis Patients: Use of Monoclonal Rheumatoid Factors as Reagents for Their Demonstration},
  author={Robert J. Winchester and Henry G. Kunkel and Vincent Agnello},
  journal={The Journal of Experimental Medicine},
  year={1971},
  volume={134},
  pages={286 - 295}
}
gammaG globulin complexed in an unusual form has been demonstrated in the serum of many patients with rheumatoid arthritis. Such complexes have been detected and isolated principally through precipitation reactions with monoclonal gammaM rheumatoid factors. These monoclonal rheumatoid factors exhibited a greater sensitivity to react with small complexes or aggregates of gamma-globulin than polyclonal rheumatoid factor from rheumatoid arthritis sera or isolated C1q. The serum complexes consisted… CONTINUE READING