Occurrence in mammalian liver of a protein which replaces the B protein of E. coli quinolinate synthetase.

@article{Sakakibara1977OccurrenceIM,
  title={Occurrence in mammalian liver of a protein which replaces the B protein of E. coli quinolinate synthetase.},
  author={Shigeki Sakakibara and Floyd Wicks and R. K. Gholson},
  journal={Biochemical and biophysical research communications},
  year={1977},
  volume={76 1},
  pages={
          158-66
        }
}
7 Citations
Evidence for an intermediate in quinolinate biosynthesis in Escherichia coli
TLDR
Results of these experiments indicate that the nadB gene product forms an unstable compound from aspartate in the presence of flavine adenine dinucleotide, and that this compound is then condensed with dihydroxyacetone phosphate to form quinolinate in a reaction catalyzed by the n adA gene product.

References

SHOWING 1-10 OF 11 REFERENCES
THE ABSENCE OF A TRYPTOPHAN-NIACIN RELATIONSHIP IN ESCHERICHIA COLI AND BACILLUS SUBTILIS
TLDR
Investigations have established tryptophan as a precursor of niacin in many organisms and led to the identification of several of the intermediates in this biosynthetic pathway (for reviews, see Dalgliesh, 1951).
Studies on the de novo biosynthesis of NAD in Escherichia coli. The separation of the nadB gene product from the nadA gene product and its purification.
TLDR
The facile separation of the wild-type quinolinate synthetase A and B proteins out of a nadC mutant suggests that quinolinic acid does not exists as a tightly bound complex.
Precursors of nicotinic acid in Escherichia coli.
TLDR
The results to be presented suggest that the probable precursors of this vitamin in E. coli are a 4-carbon dicarboxylic acid and either glycerol or a compound to which glycersol can be easily metabolized.
Cross-Feeding of Escherichia coli Mutants Defective in the Biosynthesis of Nicotinamide Adenine Dinucleotide
TLDR
Mutants of Escherichia coli defective in the biosynthesis of nicotinamide adenine dinucleotide are able to grow in a Casamino Acids medium lacking NAD and its immediate precursors, nicotinic acid and Nicotinamide, providing a means of isolating the intermediate, prequinolinic acid, as well as a biological assay for the compound.
Isolation of a metabolite capable of differentially supporting the growth of nicotinamide adenine dinucleotide auxotrophs of Escherichia coli
TLDR
A compound, isolated from the culture fluid of a nadC auxotroph of Escherichia coli grown in a minimal medium, supports the growth of both a nnA and a ndB mutant, which may be the precursor of quinolinic acid, an intermediate in the biosynthesis of nicotinamide adenosine dinucleotide.
GROWTH-RETARDING EFFECT OF CORN IN NICOTINIC ACID-LOW RATIONS AND ITS COUNTERACTION BY TRYPTOPHANE
Either 50 mg 1(-)tryptophane or 1.0 mg nicotinic acid per 100 gms of ration completely counteracts the growth retardation caused by the inclusion of 40 per cent. corn grits in a low protein ration. A
Pyrimidine biosynthesis in Escherichia coli.
...
...