Occurrence, synthesis, and mammalian cell cytotoxicity and genotoxicity of haloacetamides: an emerging class of nitrogenous drinking water disinfection byproducts.

@article{Plewa2008OccurrenceSA,
  title={Occurrence, synthesis, and mammalian cell cytotoxicity and genotoxicity of haloacetamides: an emerging class of nitrogenous drinking water disinfection byproducts.},
  author={Michael J. Plewa and Mark G. Muellner and Susan D. Richardson and Francesca Fasano and Katherine M Buettner and Yin‐tak Woo and A Bruce Mckague and Elizabeth D. Wagner},
  journal={Environmental science \& technology},
  year={2008},
  volume={42 3},
  pages={
          955-61
        }
}
The haloacetamides, a class of emerging nitrogenous drinking water disinfection byproduct (DBPs), were analyzed for their chronic cytotoxicity and for the induction of genomic DNA damage in Chinese hamster ovary cells. The rank order for cytotoxicity of 13 haloacetamides was DIAcAm > IAcAm > BAcAm > TBAcAm > BIAcAm > DBCAcAm > CIAcAm > BDCAcAm > DBAcAm > BCAcAm > CAcAm > DCAcAm > TCAcAm. The rank order of their genotoxicity was TBAcAm > DIAcAm approximately equal to IAcAm > BAcAm > DBCAcAm… 
Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by‐products
TLDR
Systematic, comparative, in vitro toxicological data provides the water supply community with information to consider when employing alternatives to chlorine disinfection, and aid in prioritizing DBPs and their related compounds for future in vivo toxicological studies and risk assessment.
Identification, Occurrence, and Cytotoxicity of Haloanilines: A New Class of Aromatic Nitrogenous Disinfection Byproducts in Chloraminated and Chlorinated Drinking Water.
Identifying disinfection byproducts (DBPs) with high health risk is an unresolved challenge. In this study, six members of a new class of aromatic nitrogenous DBPs─2-chloroaniline, 2-bromoaniline,
Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water.
TLDR
This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells, and found the HALs were highly cytotoxic compared to other DBP chemical classes.
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