Occupational respiratory and skin sensitization caused by polyfunctional aziridine hardener

@article{Kanerva1995OccupationalRA,
  title={Occupational respiratory and skin sensitization caused by polyfunctional aziridine hardener},
  author={Lasse Kanerva and Helena Keskinen and Pekka Autio and Tuula Estlander and Matti Tuppurainen and Riitta Jolanki},
  journal={Clinical \& Experimental Allergy},
  year={1995},
  volume={25}
}
Polyfunctional aziridine (PFA) is increasingly used as a water‐based crosslinker in two‐component paints, paint primers, lacquers, topcoats and other protective coatings. The crosslinker is made by reacting multifunctional acrylic monomer with a highly reactive aziridine compound. Respiratory allergy or hypersensitivity from PFA has not been reported previously. During 1978–1991 we came across nine cases with hypersensitivity from PFA: two had allergic contact dermatitis (ACD), four had… 
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References

SHOWING 1-10 OF 37 REFERENCES
Contact allergy to aziridine paint hardener.
A painter experienced an extensive dermatitis when exposed to a paint primer (undercoating) used to protect wood siding. The primer was an acrylic emulsion with a polyfunctional aziridine added as a
Contact allergy to trimethylolpropane triacrylate (TMPTA) in an aziridine plastic hardener
TLDR
4 workers developed hand and face dermatitis when exposed to a floor top coal that contained a polyurethane arid a polyfunctional aziridine hardener and additives and TMPTA, and are known sensitizers in UV‐hardening acrylates.
Immediate and delayed allergy from epoxy resins based on diglycidyl ether of bisphenol A.
TLDR
Two patients with immediate and delayed allergy to epoxy resins based on diglycidyl ether of bisphenol A (DGEBA) are presented, one of whom had been occupationally exposed to methyl tetrahydrophthalic anhydride and had a histamine-size prick test reaction to the HSA conjugate of MTHPA; the other did not react to the conjugates.
Dermatitis from aziridine hardener in Printing ink
TLDR
The incidence of dermatitis was highest among the ink mixers who handled the undiluted aziridine, was lower among printers who handled ink containing 2 to 4% azIRidine, and was absent in workers who did not handle ink.
Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody.
A single accidental exposure may result in a chemical burn, primary sensitization and allergic contact dermatitis
TLDR
Clinical cases in which a single exposure to concentrated antigen resulted in contact dermatitis suspected to be allergic were collected, and allergy to the allergens described must be considered strong allergens were revealed.
Dimethyl ethanolamine-induced asthma.
TLDR
To the knowledge, this is the first report of asthma and/or rhinitis induced specifically by dimethyl ethanolamine and the mechanism of the specific reactivity is not known.
Immediate and delayed allergy to nickel with contact urticaria, rhinitis, asthma and contact dermatitis
TLDR
This is the first patient, to the best of the authors' knowledge, reported to have developed allergic contact dermatitis, allergic contact urticaria, rhinitis and asthma from nickel.
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