Occupational respiratory and skin sensitization caused by polyfunctional aziridine hardener

  title={Occupational respiratory and skin sensitization caused by polyfunctional aziridine hardener},
  author={Lasse Kanerva and Helena Keskinen and Pekka Autio and Tuula Estlander and Matti Tuppurainen and Riitta Jolanki},
  journal={Clinical \& Experimental Allergy},
Polyfunctional aziridine (PFA) is increasingly used as a water‐based crosslinker in two‐component paints, paint primers, lacquers, topcoats and other protective coatings. The crosslinker is made by reacting multifunctional acrylic monomer with a highly reactive aziridine compound. Respiratory allergy or hypersensitivity from PFA has not been reported previously. During 1978–1991 we came across nine cases with hypersensitivity from PFA: two had allergic contact dermatitis (ACD), four had… 
Occupational allergic contact dermatitis and contact urticaria caused by polyfunctional aziridine hardener
The positive reactions with the PFA hardener and the negative reactions withThe starting chemicals and additives in PFA, namely acrylates, propyleneimine and dimethylethanolamine, indicate that PFA caused ACD.
Occupational allergic contact dermatitis to polyfunctional aziridine crosslinker in a ‘tufter’
A 55-year-old man presented with a 12-month history of an itchy, dry, erythematous rash, which initially affected his face, upper chest, and hands, and this is the first report of ACD caused by PFA crosslinker in a ‘tufter’.
Occupational contact dermatitis caused by polyfunctional aziridine crosslinker: duct tubing for airconditioning
An otherwise-healthy 39-year-old machine operator presented with erythematous papules and scaling of his antecubitals, neck and fingertips of 1-year duration, which had developed after his employer switched to an adhesive containing a polyfunctional aziridine crosslinker.
Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker.
A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to
Contact urticaria caused by obeche wood (Triplochiton scleroxylon)
A 43-year-old carpenter was referred for investigation because of symptoms of occupational rhinitis and asthma, and a bronchial provocation test showed that he had developed occupational asthma from obeche dust.
Cutaneous sensitization to aziridine preceding the onset of occupational asthma.
The onset of occupational dermatitis before asthma is consistent with the hypothesis that the sensitization to PFA was triggered in the skin, and the observation that the reactions elicited in skin and airways upon exposure to P FA exhibited the same time course, suggests a similar mechanism at both sites.
Allergic and irritant patch test reactions to plastic and glue allergens.
Although half of the plastic chemicals gave no allergic patch-test reactions during a 6-year period, with unusual allergens this low yield needs to be accepted, because otherwise rare allergies will not be detected.
Patch-test reactions to plastic and glue allergens.
Pentaerythritol‐esterified gum rosin as a sensitizer in Granuflex® hydrocolloid dressing
7 GranuflexA patients were recalled for further patch testing because of the unmodified colophony fraction in the commercial product, and reactions previously attributed to PEGR have all been accompanied by positive reactions to Colophony 20% pet.
Contact Dermatitis in Cabinet Makers
As taxonomy and science have advanced, we have become more adept not only at identifying and classifying the woods that can cause health problems in general, but at clarifying the specific physical


Contact allergy to aziridine paint hardener.
A painter experienced an extensive dermatitis when exposed to a paint primer (undercoating) used to protect wood siding. The primer was an acrylic emulsion with a polyfunctional aziridine added as a
Contact allergy to trimethylolpropane triacrylate (TMPTA) in an aziridine plastic hardener
4 workers developed hand and face dermatitis when exposed to a floor top coal that contained a polyurethane arid a polyfunctional aziridine hardener and additives and TMPTA, and are known sensitizers in UV‐hardening acrylates.
Immediate and delayed allergy from epoxy resins based on diglycidyl ether of bisphenol A.
Two patients with immediate and delayed allergy to epoxy resins based on diglycidyl ether of bisphenol A (DGEBA) are presented, one of whom had been occupationally exposed to methyl tetrahydrophthalic anhydride and had a histamine-size prick test reaction to the HSA conjugate of MTHPA; the other did not react to the conjugates.
Dermatitis from aziridine hardener in Printing ink
The incidence of dermatitis was highest among the ink mixers who handled the undiluted aziridine, was lower among printers who handled ink containing 2 to 4% azIRidine, and was absent in workers who did not handle ink.
Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody.
A single accidental exposure may result in a chemical burn, primary sensitization and allergic contact dermatitis
Clinical cases in which a single exposure to concentrated antigen resulted in contact dermatitis suspected to be allergic were collected, and allergy to the allergens described must be considered strong allergens were revealed.
Dimethyl ethanolamine-induced asthma.
To the knowledge, this is the first report of asthma and/or rhinitis induced specifically by dimethyl ethanolamine and the mechanism of the specific reactivity is not known.
Immediate and delayed allergy to nickel with contact urticaria, rhinitis, asthma and contact dermatitis
This is the first patient, to the best of the authors' knowledge, reported to have developed allergic contact dermatitis, allergic contact urticaria, rhinitis and asthma from nickel.