Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: a systematic review and meta-analysis

@article{Wagner2014OccupationalPA,
  title={Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: a systematic review and meta-analysis},
  author={Mandy Wagner and Ulrich Bolm-Audorff and Janice Hegewald and Alba Fishta and Peter Schlattmann and Jochen Schmitt and Andreas Seidler},
  journal={Occupational and Environmental Medicine},
  year={2014},
  volume={72},
  pages={226 - 233}
}
Polycyclic aromatic hydrocarbons (PAH) are genotoxic substances formed during combustion. Occupational PAH exposure has been shown to increase the risk of lung cancer and may be associated with other respiratory cancers. We conducted a systematic review and meta-analysis to clarify the relationship between occupational PAH exposures and larynx malignancies. We searched EMBASE and MEDLINE (until July 2014) using a series of search strings developed to seek case–control studies or longitudinal… 
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Occupational exposure to polycyclic aromatic hydrocarbons and lymphatic and hematopoietic neoplasms: a systematic review and meta-analysis of cohort studies
TLDR
No significant excess risk of any lymphatic and hematopoietic neoplasms was found among workers employed in jobs or industries entailing high PAH exposure, and there was no association between occupation entailed highPAH exposure and risk of MM or leukemia.
PAH exposure-associated lung cancer: an updated meta-analysis.
TLDR
Coal/coke industry and iron/steel industry workers showed a higher risk of lung cancer compared with other occupations exposed to PAHs, and the confounding effects of smoking and individual exposure levels of PAH should be taken into account.
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The study suggests the significant odds of association between urinary OH-PAH metabolites and diabetes.
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TLDR
Environmental PAH exposure among the adult population is associated with non-carcinogenic but not cancer mortality, and future studies are warranted to determine the underlying mechanisms related to these findings.
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TLDR
In most populations, occupational exposures are likely to play a minor role in laryngeal carcinogenesis, but the evidence for a causal association is strong for asbestos and strong inorganic acid mists.
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TLDR
PAHs may have toxic effects, possibly mediated by inflammation and blood lipids, on the adolescent female liver, and additional confirmatory studies are needed.
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TLDR
Comparing four GT variants in terms of efficacy and acceptable genotoxic hazard found that a combination of 4% or 5% of CCT and UVA and UVB seems to be acceptable (variants G2 and G4).
Effects of exposure to polycyclic aromatic hydrocarbons combined with high‐risk human papillomavirus infection on cervical intraepithelial neoplasia: A population study in Shanxi Province, China
TLDR
The study revealed that high exposure to PAHs could increase the risk for CIN, and it posed stronger risk when combined with HR‐HPV infection, and the results from the generalized multifactor dimensionality reduction model showed that there were joint interactions ofPAHs, HPV16, HPV58 and HPV52 on the risk of CIN2/3.
Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders
Polycyclic aromatic hydrocarbons (PAHs) are universal toxic chemicals produced mainly due to improper combustion of organic substances like wood, coal, petrol, oil, etc. Release of these pollutants…
An in vitro cytotoxicities comparison of 16 priority polycyclic aromatic hydrocarbons in human pulmonary alveolar epithelial cells HPAEpiC.
TLDR
Most of the PAHs showed benzene-ring-related cytotoxicity, except PA with 3-ring structure, which is similar to those of FL and Pyr with 4- ring structure, and the need for more studies on DBA, IND, and BghiP, among others, which are rarely investigated.
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