Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: a systematic review and meta-analysis

@article{Wagner2014OccupationalPA,
  title={Occupational polycyclic aromatic hydrocarbon exposure and risk of larynx cancer: a systematic review and meta-analysis},
  author={Mandy Wagner and Ulrich Bolm-Audorff and Janice Hegewald and Alba Fishta and Peter Schlattmann and Jochen Schmitt and Andreas Seidler},
  journal={Occupational and Environmental Medicine},
  year={2014},
  volume={72},
  pages={226 - 233}
}
Polycyclic aromatic hydrocarbons (PAH) are genotoxic substances formed during combustion. Occupational PAH exposure has been shown to increase the risk of lung cancer and may be associated with other respiratory cancers. We conducted a systematic review and meta-analysis to clarify the relationship between occupational PAH exposures and larynx malignancies. We searched EMBASE and MEDLINE (until July 2014) using a series of search strings developed to seek case–control studies or longitudinal… Expand
Occupational exposure to polycyclic aromatic hydrocarbons and lymphatic and hematopoietic neoplasms: a systematic review and meta-analysis of cohort studies
TLDR
No significant excess risk of any lymphatic and hematopoietic neoplasms was found among workers employed in jobs or industries entailing high PAH exposure, and there was no association between occupation entailed highPAH exposure and risk of MM or leukemia. Expand
PAH exposure-associated lung cancer: an updated meta-analysis.
TLDR
Coal/coke industry and iron/steel industry workers showed a higher risk of lung cancer compared with other occupations exposed to PAHs, and the confounding effects of smoking and individual exposure levels of PAH should be taken into account. Expand
The association between urinary metabolites of polycyclic aromatic hydrocarbons and diabetes: A systematic review and meta-analysis study.
TLDR
The study suggests the significant odds of association between urinary OH-PAH metabolites and diabetes. Expand
Polycyclic aromatic hydrocarbon metabolites and mortality risk in an adult population
TLDR
Environmental PAH exposure among the adult population is associated with non-carcinogenic but not cancer mortality, and future studies are warranted to determine the underlying mechanisms related to these findings. Expand
Occupational Risk Factors of Laryngeal Cancer
TLDR
In most populations, occupational exposures are likely to play a minor role in laryngeal carcinogenesis, but the evidence for a causal association is strong for asbestos and strong inorganic acid mists. Expand
Urinary biomarkers of polycyclic aromatic hydrocarbons and their associations with liver function in adolescents.
TLDR
PAHs may have toxic effects, possibly mediated by inflammation and blood lipids, on the adolescent female liver, and additional confirmatory studies are needed. Expand
Genotoxic effect of simultaneous therapeutic exposure to polycyclic aromatic hydrocarbons and UV radiation
TLDR
Comparing four GT variants in terms of efficacy and acceptable genotoxic hazard found that a combination of 4% or 5% of CCT and UVA and UVB seems to be acceptable (variants G2 and G4). Expand
Effects of exposure to polycyclic aromatic hydrocarbons combined with high‐risk human papillomavirus infection on cervical intraepithelial neoplasia: A population study in Shanxi Province, China
TLDR
The study revealed that high exposure to PAHs could increase the risk for CIN, and it posed stronger risk when combined with HR‐HPV infection, and the results from the generalized multifactor dimensionality reduction model showed that there were joint interactions ofPAHs, HPV16, HPV58 and HPV52 on the risk of CIN2/3. Expand
Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders
Polycyclic aromatic hydrocarbons (PAHs) are universal toxic chemicals produced mainly due to improper combustion of organic substances like wood, coal, petrol, oil, etc. Release of these pollutantsExpand
An in vitro cytotoxicities comparison of 16 priority polycyclic aromatic hydrocarbons in human pulmonary alveolar epithelial cells HPAEpiC.
TLDR
Most of the PAHs showed benzene-ring-related cytotoxicity, except PA with 3-ring structure, which is similar to those of FL and Pyr with 4- ring structure, and the need for more studies on DBA, IND, and BghiP, among others, which are rarely investigated. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 107 REFERENCES
Lung Cancer Risk after Exposure to Polycyclic Aromatic Hydrocarbons: A Review and Meta-Analysis
TLDR
A review and meta-analysis of published reports of occupational epidemiologic studies providing a more secure basis for risk assessment than was previously available and limited information on total dust exposure did not suggest that dust exposure was an important confounder or modified the effect. Expand
Occupational Exposures and Cancer of the Larynx—Systematic Review and Meta-analysis
TLDR
Exposures to wood dust, formaldehyde, and cement dust were not significantly associated with laryngeal cancer, and the role of solvents could not be concluded on. Expand
Occupation, exposure to polycyclic aromatic hydrocarbons and laryngeal cancer risk
TLDR
A differential effect by glutathione‐S‐transferases‐M1 genotype was found, however, small numbers do not allow firm conclusions on effect modification, and this study contributes to classifying polycyclic aromatic hydrocarbons as a risk factor for laryngeal cancer. Expand
Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium
TLDR
Occupational exposure limits for Cr(VI) based on excess absolute risks can be derived from published data identified by a systematic literature review. Expand
Cancer in asbestos-exposed occupational cohorts: a meta-analysis
TLDR
A wide variability of the association between occupational asbestos and lung cancer is demonstrated and there was a suggestion of an association between asbestos and laryngeal carcinoma and no clear association with other cancers. Expand
Occupation and larynx and hypopharynx cancer: a job-exposure matrix approach in an international case–control study in France, Italy, Spain and Switzerland
TLDR
In this study occupational exposure to solvents was associated with an increased risk of hypopharyngeal/laryngeAl cancer and results provide additional evidence of an excess of risk for exposure to asbestos. Expand
Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005.
TLDR
Increased risks from lung and bladder cancers were found in PAH-related occupations, apart from those for coal gasification, and whether they were due at least partially to some bias or confounding remains open to discussion. Expand
Cancer incidence among workers in six Norwegian aluminum plants.
TLDR
The study showed an association between bladder cancer and exposure to PAH, but gave no support to a association between PAH exposure and lung cancer in the primary aluminum industry. Expand
Exposure to nitrosamines, carbon black, asbestos, and talc and mortality from stomach, lung, and laryngeal cancer in a cohort of rubber workers.
TLDR
It is suggested that the increased mortality from lung and stomach cancer among rubber workers is associated with exposure to asbestos and dust, respectively. Expand
Occupational Exposures and Laryngeal Cancer among Non-smoking and Non-drinking Men
TLDR
An observed excess risk from silica and PAH exposure among NSND laryngeal cancer cases supports the suggested link between occupational exposure and larynGEal cancer. Expand
...
1
2
3
4
5
...