Occupational exposure to pesticides and bladder cancer risk.


BACKGROUND In the developed world, occupational exposures are a leading cause of bladder cancer. A few studies have suggested a link between pesticide exposures among agricultural populations and bladder cancer. METHODS We used data from the Agricultural Health Study, a prospective cohort study which includes 57 310 pesticide applicators with detailed information on pesticide use, to evaluate the association between pesticides and bladder cancer. We used Poisson regression to calculate rate ratios (RRs) and 95% confidence intervals (CIs) to estimate the association between each of 65 pesticides and 321 incident bladder cancer cases which accrued over the course of follow-up (1993-2011), adjusting for lifestyle and demographic and non-pesticide farm-related exposures, including those previously linked to bladder cancer. We conducted additional analyses stratified by smoking status (never, former, current). RESULTS We observed associations with bladder cancer risk for two imidazolinone herbicides, imazethapyr and imazaquin, which are aromatic amines. Ever use of imazaquin (RR = 1.54, 95% CI: 1.05, 2.26) was associated with increased risk whereas the excess risk among users of imazethapyr was evident among never smokers (RR in highest quartile vs non-exposed = 3.03, 95% CI: 1.46, 6.29, P-interaction = 0.005). We also observed increased risks overall and among never smokers for use of several chlorinated pesticides including chlorophenoxy herbicides and organochlorine insecticides. CONCLUSIONS Several associations between specific pesticides and bladder cancer risk were observed, many of which were stronger among never smokers, suggesting that possible risk factors for bladder cancer may be more readily detectable in those unexposed to potent risk factors like tobacco smoke.

DOI: 10.1093/ije/dyv195

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@article{Koutros2016OccupationalET, title={Occupational exposure to pesticides and bladder cancer risk.}, author={Stella Koutros and Debra T . Silverman and Michael Cr Alavanja and Gabriella Andreotti and Catherine C Lerro and Sonya L Heltshe and Charles F. Lynch and Dale P Sandler and Aaron E. Blair and Laura E. Beane Freeman}, journal={International journal of epidemiology}, year={2016}, volume={45 3}, pages={792-805} }