Occupational exposure to low levels of benzene: Biomarkers of exposure and nucleic acid oxidation and their modulation by polymorphic xenobiotic metabolizing enzymes.

@article{Manini2010OccupationalET,
  title={Occupational exposure to low levels of benzene: Biomarkers of exposure and nucleic acid oxidation and their modulation by polymorphic xenobiotic metabolizing enzymes.},
  author={Paola Manini and Giuseppe De Palma and Roberta Andreoli and Paola Mozzoni and Diana Poli and Matteo Goldoni and Marta Petyx and Pietro Apostoli and Antonio Mutti},
  journal={Toxicology letters},
  year={2010},
  volume={193 3},
  pages={229-35}
}
This study investigated nucleic acid oxidation associated with exposure to benzene at low levels in 239 workers recruited among traffic policemen, taxi drivers and gasoline pump attendants of the city of Parma (Italy). Biomarkers of exposure, namely urinary t,t-muconic acid (t,t-MA) and S-phenylmercapturic acid (S-PMA), urinary cotinine, and urinary biomarkers of nucleic acid oxidation, namely 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8… CONTINUE READING