Occupational airborne contact allergy to tetrazepam in a geriatric nurse

  title={Occupational airborne contact allergy to tetrazepam in a geriatric nurse},
  author={Kristine Breuer and Margitta Worm and Christoph Skudlik and Claudia Schr{\"o}der and Swen Malte John},
  journal={JDDG: Journal der Deutschen Dermatologischen Gesellschaft},
  • K. Breuer, M. Worm, +2 authors S. John
  • Published 1 October 2009
  • Medicine
  • JDDG: Journal der Deutschen Dermatologischen Gesellschaft
A 52‐year‐old geriatric nurse presented with recurrent eczema localized in uncovered skin areas. Patch testing produced an eczematous skin reaction with type IV sensitization to tetrazepam. A relapse of contact dermatitis was successfully prevented by using occupational skin protection measures and organizational measures. Our case indicates that a sensitization to drugs should be considered when allergic contact dermatitis is suspected in nursing personnel. 
Occupational contact sensitization in female geriatric nurses: Data of the Information Network of Departments of Dermatology (IVDK) 2005–2014
Little is known whether the relevant occupational allergen spectrum reported in the 1990s, including fragrances, preservatives, rubber chemicals and ingredients of surface disinfectants to be the most common sensitizers in GN, is still valid.
Airborne contact dermatitis to tetrazepam in geriatric nurses – a report of 10 cases
Background  Tetrazepam, a benzodiazepine, is a frequently used muscle relaxant. The most common adverse reactions are neurological and gastrointestinal. Cutaneous reactions to tetrazepam are rare and
Airborne contact dermatitis to drugs.
This review of the literature focuses on airborne contact dermatitis due to pharmaceutical compounds, which occurs mainly in employees of pharmaceutical industries involved in the production of the drugs and healthcare workers who use the drugs for therapeutic aims.
Occupational contact allergy in nurses: results from the Information Network of Departments of Dermatology 2003–2012
An increased prevalence of sensitization to thiurams, glutaraldehyde, formaldehyde and glyoxal in nurses with occupational contact dermatitis (OCD) has been known since the 1990s.
Occupational allergic contact dermatitis from tetrazepam in nurses
Tetrazepam is a muscle relaxant belonging to the benzodiazepine group and its use in clinical practice is regulated by the Food and Drug Administration.
Occupational airborne contact dermatitis from benzodiazepines and other drugs
Healthcare workers (or relatives) crushing drug tablets for patients with difficulties in swallowing are at risk of developing sensitization via airborne exposure through airborne exposure to Tetrazepam.
Epidemiological data on airborne contact dermatitis – results of the IVDK
Airborne contact dermatitis (AirbCD) is not uncommon, according to a large number of published case reports and review articles. Epidemiological data on AirbCD based on larger clinical samples have
An update on airborne contact dermatitis: 2007–2011
This review focuses on irritant and allergic airborne contact dermatitis in patients with known or suspected eczema and aims to establish a causal relationship between these conditions and each other.
On the clinical evidence leading to tetrazepam withdrawal
It is failed to find a turning point in the amount of ADRs reported following tetrazepam withdrawal to underpin the validity of the withdrawal, and the importance of a better communication of knowledge in scientific literature, pharmacovigilance agencies, and from doctors is stressed to prevent marketed usage of drugs with well-established side effects during long periods.
Methods for the Post-Marketing Monitoring of Psychotropics Safety: Interests and Pitfalls
The tools that can be used for the post-marketing monitoring of psychotropics safety include (i) pharmacovigilance and individual case analysis, (ii) pharmacoepidemiology and population data analysis and (iii) meta-analysis and clinical trial data analysis.


Cross‐reactive Type IV hypersensitivity reactions to benzodiazepines revealed by patch testing
The 3 patients who reacted only to their own epoxy resin underline the importance of patch testing patients to their Own epoxy resins when investigating occupational cases and may not always be standard (diglycidyl ether of bisphenol A).
Decreasing incidence of occupational contact urticaria caused by natural rubber latex allergy in German health care workers.
Reducing the purchase of powdered NRL gloves is associated with a decrease in suspected and proved cases of occupational contact urticaria caused by NRL, indicating that development of occupationally caused contact Urticaria by NRL can be reduced by banning the use of powdered NFL gloves.
Tetrazepam drug sensitivity − usefulness of the patch test
Although the optimal patch test concentration of tetrazepam has still to be determined, it is a useful diagnostic tool to confirm sensitization, particularly in patients with severe bullous eruptions.
Delayed hypersensitivity to tetrazepam
The attempt to reproduce CU lesions during remission with the patient's serum dating from a symptomatic period failed, suggesting that no cold-sensitive factor was present in the serum or that it was removed by freezing and/or storage of the serum.
Hand eczema in geriatric nurses in Germany – prevalence and risk factors
The aim of this cross‐sectional study was to collect data on the prevalence of hand eczema and relevant risk factors in geriatric nurses in Germany.
Contact dermatitis from diazepoxides
A 37-year-old housewife developed eczema on the forefinger of theright hand in December 1991, which later spread to the dorsum of the right hand, eyelids, neck and cheeks, finding positive reactions to clorazepate and valpromide.
Occupational airborne allergic
  • Contact Dermatitis
  • 1995